THE BASIC PRINCIPLES OF SOK

The operate of SIK1 in tumorigenesis. SIK1 is actually a tumor suppressor gene, which plays a very important regulatory role in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on most cancers mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may m

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